Assay Detail
Functional
CHEMBL649128
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Negative chronotropic activity for A2 Adenosine receptor as vasodilation in rat aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.34 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113419 | — | — | 1 | 6.94 |
| CHEMBL2113404 | — | — | 1 | 6.80 |
| CHEMBL2113486 | — | — | 1 | 6.11 |
| CHEMBL2113416 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113419 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2113404 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL2113486 | — | EC50 | = | 779.0 | nM | 6.11 |
| CHEMBL2113416 | — | EC50 | = | 3030.0 | nM | 5.52 |