Assay Detail
Binding
CHEMBL649131
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Inhibition of [3H]NECA binding to A2 adenosine receptor of PC12 cell membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.66 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327708 | — | — | 1 | 5.05 |
| CHEMBL89920 | — | — | 1 | 4.58 |
| CHEMBL89939 | — | — | 1 | 4.35 |
| CHEMBL90702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327708 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL89920 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL89939 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL90702 | — | IC50 | > | 100000.0 | nM | - |