Assay Detail
Binding
CHEMBL649134
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Inhibitory activity against Acetylcholinesterase (AChE)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.60 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443499 | — | — | 1 | 5.25 |
| CHEMBL1115 | PYRIDOSTIGMINE | 4.0 | 1 | 4.71 |
| CHEMBL173955 | — | — | 1 | 4.41 |
| CHEMBL422905 | — | — | 1 | 4.34 |
| CHEMBL173694 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443499 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL1115 | PYRIDOSTIGMINE | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL173955 | — | Ki | = | 38800.1 | nM | 4.41 |
| CHEMBL422905 | — | Ki | = | 45900.1 | nM | 4.34 |
| CHEMBL173694 | — | Ki | = | 52110.0 | nM | 4.28 |