Assay Detail
Binding
CHEMBL649152
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Binding affinity was determined on human cloned alpha-1B adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.12 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139505 | — | — | 1 | 8.38 |
| CHEMBL444590 | — | — | 1 | 8.10 |
| CHEMBL344432 | — | — | 1 | 7.58 |
| CHEMBL2112779 | — | — | 1 | 7.36 |
| CHEMBL2112778 | — | — | 1 | 7.28 |
| CHEMBL138109 | — | — | 1 | 6.57 |
| CHEMBL2112774 | — | — | 1 | 6.48 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139505 | — | Ki | = | 4.21 | nM | 8.38 |
| CHEMBL444590 | — | Ki | = | 7.88 | nM | 8.10 |
| CHEMBL344432 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL2112779 | — | Ki | = | 43.3 | nM | 7.36 |
| CHEMBL2112778 | — | Ki | = | 53.1 | nM | 7.28 |
| CHEMBL138109 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2112774 | — | Ki | = | 332.0 | nM | 6.48 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 5975.0 | nM | 5.22 |