Assay Detail
Binding
CHEMBL649156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.64 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123448 | — | — | 1 | 7.82 |
| CHEMBL25467 | — | — | 1 | 7.64 |
| CHEMBL3392246 | — | — | 1 | 7.07 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 7.07 |
| CHEMBL114166 | — | — | 1 | 7.06 |
| CHEMBL3392247 | — | — | 1 | 6.63 |
| CHEMBL5483012 | — | — | 1 | 6.57 |
| CHEMBL279436 | — | — | 1 | 6.39 |
| CHEMBL284103 | — | — | 1 | 6.38 |
| CHEMBL123349 | — | — | 1 | 6.31 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 6.29 |
| CHEMBL123138 | — | — | 1 | 6.11 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.01 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123448 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL25467 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3392246 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL114166 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3392247 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL5483012 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL279436 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL284103 | — | Ki | = | 416.0 | nM | 6.38 |
| CHEMBL123349 | — | Ki | = | 485.0 | nM | 6.31 |
| CHEMBL31410 | CORYNANTHEINE | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL123138 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 966.0 | nM | 6.01 |
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 2270.0 | nM | 5.64 |