Assay Detail
Binding
CHEMBL649157
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Inhibition of binding of [125I]HEAT to cloned human alpha-1B adrenergic receptor.
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.25 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415887 | — | — | 1 | 8.18 |
| CHEMBL435576 | — | — | 1 | 7.64 |
| CHEMBL295304 | — | — | 1 | 7.47 |
| CHEMBL44294 | — | — | 1 | 6.55 |
| CHEMBL298058 | — | — | 1 | 6.44 |
| CHEMBL41677 | — | — | 1 | 6.35 |
| CHEMBL44288 | — | — | 1 | 6.24 |
| CHEMBL42220 | — | — | 1 | 6.24 |
| CHEMBL297667 | — | — | 1 | 6.19 |
| CHEMBL42514 | — | — | 1 | 6.17 |
| CHEMBL289916 | — | — | 1 | 6.17 |
| CHEMBL41844 | — | — | 1 | 6.16 |
| CHEMBL296965 | — | — | 1 | 6.08 |
| CHEMBL289339 | — | — | 1 | 6.06 |
| CHEMBL41994 | — | — | 3 | 6.05 |
| CHEMBL42156 | — | — | 1 | 6.04 |
| CHEMBL417350 | — | — | 1 | 6.02 |
| CHEMBL40303 | — | — | 1 | 5.96 |
| CHEMBL42361 | — | — | 1 | 5.92 |
| CHEMBL44496 | — | — | 1 | 5.77 |
| CHEMBL42763 | — | — | 1 | 5.72 |
| CHEMBL416073 | — | — | 1 | 5.70 |
| CHEMBL43749 | — | — | 1 | 5.48 |
| CHEMBL41959 | — | — | 1 | - |
| CHEMBL44124 | — | — | 1 | - |
| CHEMBL43799 | — | — | 1 | - |
| CHEMBL432302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415887 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL435576 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL295304 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL44294 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL298058 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL41677 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL44288 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL42220 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL297667 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL42514 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL289916 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL41844 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL296965 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL289339 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL41994 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL42156 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL417350 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL40303 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL41994 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL42361 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL41994 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL44496 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL42763 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL416073 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL43749 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL432302 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL44124 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL41959 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL43799 | — | Ki | > | 3000.0 | nM | - |