Assay Detail
Binding
CHEMBL649207
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Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.23 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60583 | — | — | 1 | 8.30 |
| CHEMBL59262 | — | — | 1 | 8.27 |
| CHEMBL556313 | — | — | 1 | 8.23 |
| CHEMBL56292 | — | — | 1 | 8.11 |
| CHEMBL301224 | — | — | 1 | 8.10 |
| CHEMBL417939 | — | — | 1 | 8.09 |
| CHEMBL56438 | — | — | 1 | 8.00 |
| CHEMBL293539 | — | — | 1 | 8.00 |
| CHEMBL298595 | — | — | 1 | 7.94 |
| CHEMBL300152 | — | — | 1 | 7.88 |
| CHEMBL55319 | — | — | 1 | 7.87 |
| CHEMBL292366 | — | — | 1 | 7.80 |
| CHEMBL57868 | — | — | 1 | 7.77 |
| CHEMBL299253 | — | — | 1 | 7.69 |
| CHEMBL55654 | — | — | 1 | 7.58 |
| CHEMBL56804 | — | — | 1 | 7.45 |
| CHEMBL299454 | — | — | 1 | 7.44 |
| CHEMBL440118 | — | — | 1 | 7.42 |
| CHEMBL57317 | — | — | 1 | 7.36 |
| CHEMBL299022 | — | — | 1 | 7.34 |
| CHEMBL56899 | — | — | 1 | 7.32 |
| CHEMBL293111 | — | — | 1 | 7.28 |
| CHEMBL294235 | — | — | 1 | 7.27 |
| CHEMBL57859 | — | — | 1 | 7.26 |
| CHEMBL431943 | — | — | 1 | 7.24 |
| CHEMBL299691 | — | — | 1 | 7.20 |
| CHEMBL291908 | — | — | 1 | 7.13 |
| CHEMBL55882 | — | — | 1 | 7.10 |
| CHEMBL56620 | — | — | 1 | 7.08 |
| CHEMBL293734 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60583 | — | Ki | = | 4.97 | nM | 8.30 |
| CHEMBL59262 | — | Ki | = | 5.38 | nM | 8.27 |
| CHEMBL556313 | — | Ki | = | 5.88 | nM | 8.23 |
| CHEMBL56292 | — | Ki | = | 7.76 | nM | 8.11 |
| CHEMBL301224 | — | Ki | = | 7.95 | nM | 8.10 |
| CHEMBL417939 | — | Ki | = | 8.21 | nM | 8.09 |
| CHEMBL56438 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL293539 | — | Ki | = | 10.05 | nM | 8.00 |
| CHEMBL298595 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL300152 | — | Ki | = | 13.11 | nM | 7.88 |
| CHEMBL55319 | — | Ki | = | 13.61 | nM | 7.87 |
| CHEMBL292366 | — | Ki | = | 15.84 | nM | 7.80 |
| CHEMBL57868 | — | Ki | = | 17.01 | nM | 7.77 |
| CHEMBL299253 | — | Ki | = | 20.25 | nM | 7.69 |
| CHEMBL55654 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL56804 | — | Ki | = | 35.56 | nM | 7.45 |
| CHEMBL299454 | — | Ki | = | 35.94 | nM | 7.44 |
| CHEMBL440118 | — | Ki | = | 37.57 | nM | 7.42 |
| CHEMBL57317 | — | Ki | = | 43.35 | nM | 7.36 |
| CHEMBL299022 | — | Ki | = | 46.18 | nM | 7.34 |
| CHEMBL56899 | — | Ki | = | 47.54 | nM | 7.32 |
| CHEMBL293111 | — | Ki | = | 52.89 | nM | 7.28 |
| CHEMBL294235 | — | Ki | = | 54.08 | nM | 7.27 |
| CHEMBL57859 | — | Ki | = | 54.99 | nM | 7.26 |
| CHEMBL431943 | — | Ki | = | 57.65 | nM | 7.24 |
| CHEMBL299691 | — | Ki | = | 62.62 | nM | 7.20 |
| CHEMBL291908 | — | Ki | = | 73.53 | nM | 7.13 |
| CHEMBL55882 | — | Ki | = | 79.62 | nM | 7.10 |
| CHEMBL56620 | — | Ki | = | 83.61 | nM | 7.08 |
| CHEMBL293734 | — | Ki | = | 84.08 | nM | 7.08 |
| CHEMBL294646 | — | Ki | = | 86.38 | nM | 7.06 |
| CHEMBL57593 | — | Ki | = | 86.96 | nM | 7.06 |
| CHEMBL58476 | — | Ki | = | 119.18 | nM | 6.92 |
| CHEMBL56869 | — | Ki | = | 122.03 | nM | 6.91 |
| CHEMBL292399 | — | Ki | = | 127.8 | nM | 6.89 |
| CHEMBL57540 | — | Ki | = | 131.95 | nM | 6.88 |
| CHEMBL431354 | — | Ki | = | 168.28 | nM | 6.77 |
| CHEMBL13647 | BMY-7378 | Ki | = | 168.2 | nM | 6.77 |
| CHEMBL59149 | — | Ki | = | 193.29 | nM | 6.71 |
| CHEMBL57364 | — | Ki | = | 220.52 | nM | 6.66 |
| CHEMBL60699 | — | Ki | = | 262.76 | nM | 6.58 |
| CHEMBL293968 | — | Ki | = | 264.47 | nM | 6.58 |
| CHEMBL292686 | — | Ki | = | 274.38 | nM | 6.56 |
| CHEMBL58384 | — | Ki | = | 447.86 | nM | 6.35 |
| CHEMBL294023 | — | Ki | = | 790.88 | nM | 6.10 |
| CHEMBL55655 | — | Ki | = | 812.58 | nM | 6.09 |
| CHEMBL55790 | — | Ki | = | 915.4 | nM | 6.04 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1882.0 | nM | 5.72 |
| CHEMBL57098 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL301019 | — | Ki | > | 1000.0 | nM | - |