Assay Detail
Binding
CHEMBL649215
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Binding affinity to hamster alpha-1B adrenergic receptor
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.36 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61483 | — | — | 1 | 9.48 |
| CHEMBL58956 | — | — | 1 | 9.18 |
| CHEMBL293695 | — | — | 1 | 9.18 |
| CHEMBL62028 | — | — | 1 | 9.13 |
| CHEMBL61598 | — | — | 1 | 9.08 |
| CHEMBL440865 | — | — | 1 | 9.04 |
| CHEMBL445071 | — | — | 1 | 9.00 |
| CHEMBL62110 | — | — | 1 | 8.98 |
| CHEMBL61491 | — | — | 1 | 8.94 |
| CHEMBL60721 | — | — | 1 | 8.89 |
| CHEMBL431720 | — | — | 1 | 8.88 |
| CHEMBL62033 | — | — | 1 | 8.81 |
| CHEMBL369154 | — | — | 1 | 8.79 |
| CHEMBL291839 | — | — | 1 | 8.79 |
| CHEMBL2115086 | — | — | 1 | 8.79 |
| CHEMBL292881 | — | — | 1 | 8.68 |
| CHEMBL291528 | — | — | 1 | 8.64 |
| CHEMBL302203 | — | — | 1 | 8.64 |
| CHEMBL294098 | — | — | 1 | 8.59 |
| CHEMBL60471 | — | — | 1 | 8.57 |
| CHEMBL432147 | — | — | 1 | 8.51 |
| CHEMBL58862 | — | — | 1 | 8.48 |
| CHEMBL60722 | — | — | 1 | 8.48 |
| CHEMBL304215 | — | — | 1 | 8.48 |
| CHEMBL293236 | — | — | 1 | 8.47 |
| CHEMBL61225 | — | — | 1 | 8.43 |
| CHEMBL60510 | — | — | 1 | 8.39 |
| CHEMBL291303 | — | — | 1 | 8.19 |
| CHEMBL294027 | — | — | 1 | 8.15 |
| CHEMBL299907 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61483 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL58956 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL293695 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL62028 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL61598 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL440865 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL445071 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL62110 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL61491 | — | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL60721 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL431720 | — | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL62033 | — | Ki | = | 1.56 | nM | 8.81 |
| CHEMBL369154 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL291839 | — | Ki | = | 1.63 | nM | 8.79 |
| CHEMBL2115086 | — | Ki | = | 1.63 | nM | 8.79 |
| CHEMBL292881 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL291528 | — | Ki | = | 2.31 | nM | 8.64 |
| CHEMBL302203 | — | Ki | = | 2.27 | nM | 8.64 |
| CHEMBL294098 | — | Ki | = | 2.58 | nM | 8.59 |
| CHEMBL60471 | — | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL432147 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL58862 | — | Ki | = | 3.31 | nM | 8.48 |
| CHEMBL304215 | — | Ki | = | 3.33 | nM | 8.48 |
| CHEMBL60722 | — | Ki | = | 3.31 | nM | 8.48 |
| CHEMBL293236 | — | Ki | = | 3.37 | nM | 8.47 |
| CHEMBL61225 | — | Ki | = | 3.76 | nM | 8.43 |
| CHEMBL60510 | — | Ki | = | 4.07 | nM | 8.39 |
| CHEMBL291303 | — | Ki | = | 6.46 | nM | 8.19 |
| CHEMBL294027 | — | Ki | = | 7.14 | nM | 8.15 |
| CHEMBL299907 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL62109 | — | Ki | = | 9.27 | nM | 8.03 |
| CHEMBL291588 | — | Ki | = | 10.57 | nM | 7.98 |
| CHEMBL58105 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL62206 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL445325 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL291769 | — | Ki | = | 16.28 | nM | 7.79 |
| CHEMBL58612 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL290387 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL291305 | — | Ki | = | 61.2 | nM | 7.21 |
| CHEMBL302192 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL303988 | — | Ki | = | 95.2 | nM | 7.02 |
| CHEMBL59575 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL58585 | — | Ki | = | 191.0 | nM | 6.72 |