Assay Detail
Binding
CHEMBL649219
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Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.71 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | 3.0 | 1 | 7.60 |
| CHEMBL677 | LEVONORDEFRIN | 4.0 | 1 | 6.69 |
| CHEMBL420652 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL677 | LEVONORDEFRIN | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL420652 | — | Ki | = | 1449.0 | nM | 5.84 |