Assay Detail
Functional
CHEMBL649235
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Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.04 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540542 | — | — | 1 | 8.25 |
| CHEMBL70692 | — | — | 1 | 7.80 |
| CHEMBL553276 | — | — | 1 | 7.55 |
| CHEMBL419448 | — | — | 1 | 6.30 |
| CHEMBL70973 | — | — | 1 | 5.30 |
| CHEMBL74071 | — | — | 1 | - |
| CHEMBL542402 | — | — | 1 | - |
| CHEMBL70326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540542 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL70692 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL553276 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL419448 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL70973 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL74071 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL542402 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL70326 | — | EC50 | < | 10000.0 | nM | - |