Assay Detail
Functional
CHEMBL649237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.11 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 8.02 |
| CHEMBL49137 | — | — | 1 | 7.85 |
| CHEMBL72753 | — | — | 1 | 7.51 |
| CHEMBL70676 | — | — | 1 | 7.26 |
| CHEMBL74283 | — | — | 1 | 6.98 |
| CHEMBL72995 | — | — | 1 | 6.08 |
| CHEMBL72147 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | EC50 | = | 9.55 | nM | 8.02 |
| CHEMBL49137 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL72753 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL70676 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL74283 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL72995 | — | EC50 | = | 831.76 | nM | 6.08 |
| CHEMBL72147 | — | EC50 | = | 831.76 | nM | 6.08 |