Assay Detail
Binding
CHEMBL649243
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Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.32 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.23 |
| CHEMBL72768 | — | — | 1 | 6.94 |
| CHEMBL540542 | — | — | 1 | 6.84 |
| CHEMBL553276 | — | — | 1 | 6.78 |
| CHEMBL70751 | — | — | 1 | 6.77 |
| CHEMBL72441 | — | — | 1 | 6.70 |
| CHEMBL70692 | — | — | 1 | 6.66 |
| CHEMBL306792 | — | — | 1 | 6.66 |
| CHEMBL419448 | — | — | 1 | 6.59 |
| CHEMBL540035 | — | — | 1 | 6.57 |
| CHEMBL70691 | — | — | 1 | 6.22 |
| CHEMBL72724 | — | — | 1 | 6.22 |
| CHEMBL74114 | — | — | 1 | 6.16 |
| CHEMBL70973 | — | — | 1 | 5.60 |
| CHEMBL554416 | — | — | 1 | 5.58 |
| CHEMBL70740 | — | — | 1 | 5.57 |
| CHEMBL70563 | — | — | 1 | 5.40 |
| CHEMBL70634 | — | — | 1 | 5.32 |
| CHEMBL71001 | — | — | 1 | - |
| CHEMBL302698 | — | — | 1 | - |
| CHEMBL74071 | — | — | 1 | - |
| CHEMBL74467 | — | — | 1 | - |
| CHEMBL544290 | — | — | 1 | - |
| CHEMBL542402 | — | — | 1 | - |
| CHEMBL71479 | — | — | 1 | - |
| CHEMBL70326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL72768 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL540542 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL553276 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL70751 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL72441 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL70692 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL306792 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL419448 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL540035 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL70691 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL72724 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL74114 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL70973 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL554416 | — | Ki | = | 2630.27 | nM | 5.58 |
| CHEMBL70740 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL70563 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL70634 | — | Ki | = | 4786.3 | nM | 5.32 |
| CHEMBL71001 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL302698 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL74071 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL74467 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL544290 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL542402 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL71479 | — | Ki | < | 5011.87 | nM | - |
| CHEMBL70326 | — | Ki | < | 5011.87 | nM | - |