Assay Detail
Binding
CHEMBL649245
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Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.04 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49137 | — | — | 1 | 7.55 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 7.08 |
| CHEMBL72753 | — | — | 1 | 6.71 |
| CHEMBL74283 | — | — | 1 | 6.67 |
| CHEMBL70676 | — | — | 1 | 6.39 |
| CHEMBL72995 | — | — | 1 | 6.19 |
| CHEMBL72147 | — | — | 1 | 6.19 |
| CHEMBL49395 | — | — | 1 | 5.85 |
| CHEMBL74342 | — | — | 1 | 4.94 |
| CHEMBL73392 | — | — | 1 | 4.55 |
| CHEMBL73164 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49137 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL72753 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL74283 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL70676 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL72995 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL72147 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL49395 | — | Ki | = | 1412.54 | nM | 5.85 |
| CHEMBL74342 | — | Ki | = | 11481.54 | nM | 4.94 |
| CHEMBL73392 | — | Ki | = | 28183.83 | nM | 4.55 |
| CHEMBL73164 | — | Ki | = | 48977.88 | nM | 4.31 |