Assay Detail
Binding
CHEMBL649311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of compound in presence of bovine serum albumin (BSA) at 0.22% against rat adrenal Angiotensin II receptor, type 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Serum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.50 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75101 | — | — | 1 | 6.24 |
| CHEMBL76943 | — | — | 1 | 5.66 |
| CHEMBL77185 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75101 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL76943 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL77185 | — | Ki | = | 24400.0 | nM | 4.61 |