Assay Detail
Binding
CHEMBL649312
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Binding affinity for Angiotensin II receptor, type 1 in rat adrenal cortical membranes using [125I]Sar1, Ile8-angiotensin II
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.42 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312066 | — | — | 1 | 8.89 |
| CHEMBL77029 | — | — | 1 | 8.35 |
| CHEMBL77935 | — | — | 1 | 8.13 |
| CHEMBL77827 | — | — | 1 | 8.05 |
| CHEMBL306278 | — | — | 1 | 7.82 |
| CHEMBL75053 | — | — | 1 | 7.77 |
| CHEMBL74445 | — | — | 1 | 7.68 |
| CHEMBL312068 | — | — | 1 | 7.66 |
| CHEMBL77376 | — | — | 1 | 7.55 |
| CHEMBL309489 | — | — | 1 | 7.36 |
| CHEMBL76785 | — | — | 1 | 7.34 |
| CHEMBL76765 | — | — | 1 | 7.30 |
| CHEMBL433310 | — | — | 1 | 7.17 |
| CHEMBL75101 | — | — | 1 | 7.15 |
| CHEMBL76943 | — | — | 1 | 6.86 |
| CHEMBL77266 | — | — | 1 | 6.72 |
| CHEMBL77185 | — | — | 1 | 6.26 |
| CHEMBL307946 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312066 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL77029 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL77935 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL77827 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL306278 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL75053 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL74445 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL312068 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL77376 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL309489 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL76785 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL76765 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL433310 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL75101 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL76943 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL77266 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL77185 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL307946 | — | Ki | = | 3450.0 | nM | 5.46 |