Assay Detail
Binding
CHEMBL649313
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Binding affinity towards Angiotensin II receptor, type 1 in rat aortic smooth muscle cells using 0.2 nM [125I]-labeled Sar-Ile-angiotensin II
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.03 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11840 | — | — | 1 | 9.22 |
| CHEMBL12233 | — | — | 1 | 8.89 |
| CHEMBL12588 | — | — | 1 | 8.70 |
| CHEMBL12013 | — | — | 1 | 8.70 |
| CHEMBL12106 | — | — | 1 | 8.70 |
| CHEMBL12175 | — | — | 1 | 8.52 |
| CHEMBL266628 | — | — | 1 | 8.40 |
| CHEMBL268706 | — | — | 1 | 8.40 |
| CHEMBL429037 | — | — | 1 | 8.30 |
| CHEMBL11706 | BMS-248360 | — | 1 | 8.22 |
| CHEMBL12592 | — | — | 1 | 8.15 |
| CHEMBL275545 | — | — | 1 | 8.10 |
| CHEMBL12779 | — | — | 1 | 8.10 |
| CHEMBL275523 | — | — | 1 | 7.89 |
| CHEMBL12557 | — | — | 1 | 7.85 |
| CHEMBL12144 | — | — | 1 | 7.80 |
| CHEMBL12590 | — | — | 1 | 7.80 |
| CHEMBL12333 | — | — | 1 | 7.68 |
| CHEMBL12172 | — | — | 1 | 7.64 |
| CHEMBL417429 | — | — | 1 | 7.62 |
| CHEMBL11528 | — | — | 1 | 7.52 |
| CHEMBL12348 | — | — | 1 | 7.46 |
| CHEMBL274154 | — | — | 1 | 7.40 |
| CHEMBL12102 | — | — | 1 | 7.29 |
| CHEMBL12703 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11840 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL12233 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL12588 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL12013 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL12106 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL12175 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL266628 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL268706 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL429037 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL11706 | BMS-248360 | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL12592 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL275545 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL12779 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL275523 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL12557 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL12144 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL12590 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL12333 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL12172 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL417429 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL11528 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL12348 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL274154 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL12102 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL12703 | — | Ki | = | 360.0 | nM | 6.44 |