Assay Detail
Binding
CHEMBL649336
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Binding affinity at Alpha-1 adrenergic receptors on rat cortical membranes by [3H]prazosin displacement.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.78 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55505 | — | — | 1 | 7.06 |
| CHEMBL292452 | — | — | 1 | 6.95 |
| CHEMBL293583 | — | — | 1 | 6.64 |
| CHEMBL54465 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55505 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL292452 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL293583 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL54465 | — | Ki | = | 337.0 | nM | 6.47 |