Assay Detail
Binding
CHEMBL649341
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Binding affinity towards alpha-1 adrenergic receptor using [3H]prazosin as radioligand.
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.24 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275045 | — | — | 1 | 9.15 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.89 |
| CHEMBL423712 | — | — | 1 | 8.85 |
| CHEMBL1161079 | — | — | 1 | 8.77 |
| CHEMBL135135 | — | — | 1 | 8.74 |
| CHEMBL443546 | — | — | 1 | 8.72 |
| CHEMBL1161076 | — | — | 1 | 8.59 |
| CHEMBL134304 | — | — | 1 | 8.57 |
| CHEMBL1161083 | — | — | 1 | 8.55 |
| CHEMBL439607 | — | — | 1 | 8.47 |
| CHEMBL135676 | — | — | 1 | 8.43 |
| CHEMBL1161126 | — | — | 1 | 8.40 |
| CHEMBL416703 | — | — | 1 | 8.40 |
| CHEMBL1161119 | — | — | 1 | 8.30 |
| CHEMBL422989 | — | — | 1 | 8.28 |
| CHEMBL135377 | — | — | 1 | 8.26 |
| CHEMBL1161088 | — | — | 1 | 8.24 |
| CHEMBL1161087 | — | — | 1 | 8.24 |
| CHEMBL334767 | — | — | 1 | 8.24 |
| CHEMBL135246 | — | — | 1 | 8.21 |
| CHEMBL1161120 | — | — | 1 | 8.21 |
| CHEMBL135938 | — | — | 1 | 8.21 |
| CHEMBL1161078 | — | — | 1 | 8.15 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.09 |
| CHEMBL135107 | — | — | 1 | 8.07 |
| CHEMBL341402 | — | — | 1 | 8.07 |
| CHEMBL1161096 | — | — | 1 | 8.04 |
| CHEMBL135479 | — | — | 1 | 7.92 |
| CHEMBL3392290 | — | — | 1 | 7.89 |
| CHEMBL1161058 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275045 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL423712 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1161079 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL135135 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL443546 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1161076 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL134304 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1161083 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL439607 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL135676 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1161126 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL416703 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1161119 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL422989 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL135377 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL334767 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1161088 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1161087 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL135246 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL1161120 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL135938 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL1161078 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL135107 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL341402 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL1161096 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL135479 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3392290 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1161058 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL340268 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL10105 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL135129 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL135047 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL134951 | — | Ki | > | 1000.0 | nM | - |