Assay Detail
Binding
CHEMBL649354
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Inhibition of aromatase activity in human placental microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Placenta |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.05 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95919 | — | — | 1 | 7.39 |
| CHEMBL95109 | — | — | 1 | 7.04 |
| CHEMBL97542 | 7-HYDROXYFLAVANONE | — | 1 | 5.42 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.28 |
| CHEMBL9687 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95919 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL95109 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL97542 | 7-HYDROXYFLAVANONE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL9687 | — | IC50 | = | 8000.0 | nM | 5.10 |