Compound Detail
CHEMBL97542
7-HYDROXYFLAVANONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL97542 |
| Name | 7-HYDROXYFLAVANONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SWAJPHCXKPCPQZ-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
240.3
MW (Da)
3.10
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.83
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aromatase CHEMBL1978 | IC50 | 5.62 | 5.4867 | 2398.8 | 3 |
| Monoamine oxidase CHEMBL2095205 | IC50 | 4.89 | 4.89 | 13000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aromatase | IC50 | = | 2398.83 | nM | 5.62 | Inhibition of human aromatase using ASD as substrate pre-incubated for 5 mins fo... | 28622580 |
| Aromatase | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of aromatase activity in human placental microsomes | 12270163 |
| Aromatase | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of human aromatase in placental microsomes | 18042388 |
| Monoamine oxidase | IC50 | = | 13000.0 | nM | 4.89 | Inhibition of hamster liver mitochondrial monoamine oxidase MAO | 11563931 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15161186 | 10.1021/jf035213x | Fusarium graminearum | 4 |
| 18042388 | 10.1016/j.bmc.2007.10.057 | Aromatase | 2 |
| 19236029 | 10.1021/np800698d | Enterococcus faecalis | 2 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Glucocorticoid receptor | 2 |
| 28622580 | 10.1016/j.ejmech.2017.05.041 | Aromatase | 1 |
| 11720850 | 10.1016/s0960-894x(01)00617-5 | MCF7 | 1 |
| 15161186 | 10.1021/jf035213x | Diaporthe longicolla | 1 |
| 15161186 | 10.1021/jf035213x | Alternaria alternata | 1 |
| 15161186 | 10.1021/jf035213x | Fusarium equiseti | 1 |
| 15161186 | 10.1021/jf035213x | Colletotrichum truncatum | 1 |
| 15161186 | 10.1021/jf035213x | Macrophomina phaseolina | 1 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Androgen receptor | 1 |
| 19236029 | 10.1021/np800698d | Unchecked | 1 |
| 19307119 | 10.1016/j.bmcl.2009.03.017 | HEK293 | 1 |
| 2607357 | 10.1021/np50065a011 | Unchecked | 1 |
| 12270163 | 10.1016/s0960-894x(02)00565-6 | Aromatase | 1 |
| 11563931 | 10.1021/jm0101390 | Monoamine oxidase | 1 |
| 11563931 | 10.1021/jm0101390 | Aldehyde dehydrogenase, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine