Assay Detail
Binding
CHEMBL932215
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Inhibition of human aromatase in placental microsomes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Placenta |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.56 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439241 | — | — | 1 | 6.21 |
| CHEMBL256665 | — | — | 1 | 6.20 |
| CHEMBL258257 | — | — | 1 | 5.86 |
| CHEMBL255108 | — | — | 1 | 5.81 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 5.70 |
| CHEMBL252642 | LIQUIRTIGENIN | — | 1 | 5.68 |
| CHEMBL255110 | — | — | 1 | 5.47 |
| CHEMBL256407 | — | — | 1 | 5.46 |
| CHEMBL402970 | — | — | 1 | 5.43 |
| CHEMBL97542 | 7-HYDROXYFLAVANONE | — | 1 | 5.42 |
| CHEMBL404225 | — | — | 1 | 5.37 |
| CHEMBL9687 | — | — | 1 | 5.10 |
| CHEMBL274318 | FLAVANONE | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439241 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL256665 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL258257 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL255108 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL252642 | LIQUIRTIGENIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL255110 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL256407 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL402970 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL97542 | 7-HYDROXYFLAVANONE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL404225 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL9687 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL274318 | FLAVANONE | IC50 | = | 28000.0 | nM | 4.55 |