Assay Detail
Binding
CHEMBL649398
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Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregates
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.36 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55380 | — | — | 1 | 9.05 |
| CHEMBL81260 | — | — | 1 | 7.99 |
| CHEMBL78012 | — | — | 1 | 7.82 |
| CHEMBL78621 | — | — | 1 | 6.62 |
| CHEMBL309920 | — | — | 1 | 6.47 |
| CHEMBL78765 | — | — | 1 | 6.20 |
| CHEMBL78410 | — | — | 1 | - |
| CHEMBL81685 | — | — | 1 | - |
| CHEMBL312622 | — | — | 1 | - |
| CHEMBL310444 | — | — | 1 | - |
| CHEMBL311035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55380 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL81260 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL78012 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL78621 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL309920 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL78765 | — | Ki | = | 638.0 | nM | 6.20 |
| CHEMBL78410 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL81685 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL312622 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL310444 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL311035 | — | Ki | > | 2000.0 | nM | - |