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Assay Detail

CHEMBL649399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Amyloid beta 1-40 aggregates fibrils in competition with BTA-1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.
Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE.
J Med Chem (2003) 46 : 2740 -2754
PubMed 12801237 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.24 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL57267 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL57267 Ki = 580.0 nM 6.24