Assay Detail
Binding
CHEMBL649400
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Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.05 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328660 | — | — | 1 | 8.77 |
| CHEMBL328430 | — | — | 1 | 8.72 |
| CHEMBL55401 | — | — | 1 | 8.54 |
| CHEMBL92816 | — | — | 1 | 8.40 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.37 |
| CHEMBL91449 | — | — | 1 | 8.36 |
| CHEMBL94230 | — | — | 1 | 8.31 |
| CHEMBL92390 | — | — | 1 | 8.15 |
| CHEMBL92852 | — | — | 1 | 8.14 |
| CHEMBL92802 | — | — | 1 | 8.07 |
| CHEMBL93109 | — | — | 1 | 8.02 |
| CHEMBL330529 | — | — | 1 | 8.00 |
| CHEMBL92801 | — | — | 1 | 7.96 |
| CHEMBL93334 | — | — | 1 | 7.96 |
| CHEMBL93118 | — | — | 1 | 7.43 |
| CHEMBL93884 | — | — | 1 | 7.34 |
| CHEMBL329640 | — | — | 1 | 7.19 |
| CHEMBL93270 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328660 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL328430 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL55401 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL92816 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL91449 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL94230 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL92390 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL92852 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL92802 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL93109 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL330529 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL92801 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL93334 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL93118 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL93884 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL329640 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL93270 | — | Ki | = | 64.0 | nM | 7.19 |