Assay Detail
Binding
CHEMBL649491
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Inhibition of [125I]AII binding to guinea pig adrenal membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New nonpeptide angiostensin II receptor antagonists. Synthesis, biological properties and structure-activity relationships of 3-substituted 2,6-dialkyl-4-(biphenyll)methylaminopyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.08 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33459 | — | — | 1 | 8.58 |
| CHEMBL33811 | — | — | 1 | 8.46 |
| CHEMBL32649 | — | — | 1 | 8.42 |
| CHEMBL418226 | — | — | 1 | 8.30 |
| CHEMBL33226 | — | — | 1 | 8.21 |
| CHEMBL34044 | — | — | 1 | 8.18 |
| CHEMBL32648 | — | — | 1 | 8.12 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.10 |
| CHEMBL285176 | — | — | 1 | 8.10 |
| CHEMBL285560 | — | — | 1 | 7.85 |
| CHEMBL33403 | — | — | 1 | 7.60 |
| CHEMBL287230 | — | — | 1 | 7.58 |
| CHEMBL284536 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33459 | — | IC50 | = | 2.64 | nM | 8.58 |
| CHEMBL33811 | — | IC50 | = | 3.48 | nM | 8.46 |
| CHEMBL32649 | — | IC50 | = | 3.83 | nM | 8.42 |
| CHEMBL418226 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL33226 | — | IC50 | = | 6.21 | nM | 8.21 |
| CHEMBL34044 | — | IC50 | = | 6.65 | nM | 8.18 |
| CHEMBL32648 | — | IC50 | = | 7.58 | nM | 8.12 |
| CHEMBL191 | LOSARTAN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL285176 | — | IC50 | = | 8.03 | nM | 8.10 |
| CHEMBL285560 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL33403 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL287230 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL284536 | — | IC50 | = | 31.0 | nM | 7.51 |