Assay Detail
Binding
CHEMBL649501
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Inhibitory activity against Angiotensin II receptor, type 1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.87 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160494 | — | — | 1 | 9.62 |
| CHEMBL100119 | — | — | 1 | 9.59 |
| CHEMBL60942 | — | — | 1 | 9.00 |
| CHEMBL291803 | — | — | 1 | 8.52 |
| CHEMBL42101 | — | — | 1 | 8.24 |
| CHEMBL275875 | CL-329167 | — | 1 | 8.22 |
| CHEMBL294558 | — | — | 1 | - |
| CHEMBL34124 | OLODANRIGAN | 2.0 | 1 | - |
| CHEMBL157946 | — | — | 1 | - |
| CHEMBL290286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160494 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL100119 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL60942 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL291803 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL42101 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL275875 | CL-329167 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL294558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL34124 | OLODANRIGAN | IC50 | > | 100000.0 | nM | - |
| CHEMBL157946 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL290286 | — | IC50 | > | 100000.0 | nM | - |