Assay Detail
Functional
CHEMBL649515
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Tested in vitro for amylase release from rat pancreatic acini (percent of secretion)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.97 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274661 | — | — | 1 | 8.52 |
| CHEMBL262155 | — | — | 1 | 8.40 |
| CHEMBL216079 | — | — | 1 | 8.22 |
| CHEMBL441165 | — | — | 1 | 7.70 |
| CHEMBL217424 | — | — | 1 | 7.70 |
| CHEMBL217234 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274661 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL262155 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL216079 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL441165 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL217424 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL217234 | — | EC50 | = | 50.0 | nM | 7.30 |