Compound Detail
CHEMBL274661
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1
Basic Information
| ChEMBL ID | CHEMBL274661 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | JFJZBYATNAUMLS-FDXDWZSASA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1034.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.7
EC50 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gastrin/cholecystokinin type B receptor CHEMBL298 | IC50 | 8.7 | 8.7 | 2.0 | 2 |
| Pancreatic alpha-amylase CHEMBL2045 | EC50 | 8.52 | 8.52 | 3.0 | 1 |
| Gastrin/cholecystokinin type B receptor CHEMBL3508 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gastrin/cholecystokinin type B receptor | IC50 | = | 2.0 | nM | 8.7 | Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guin... | 7692048 |
| Gastrin/cholecystokinin type B receptor | IC50 | = | 2.0 | nM | 8.7 | Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurk... | 7692048 |
| Pancreatic alpha-amylase | EC50 | = | 3.0 | nM | 8.52 | Tested in vitro for amylase release from rat pancreatic acini (percent of secret... | 7692048 |
| Gastrin/cholecystokinin type B receptor | IC50 | = | 3.0 | nM | 8.52 | Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B recepto... | 7692048 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7692048 | 10.1021/jm00072a024 | Gastrin/cholecystokinin type B receptor | 3 |
| 7692048 | 10.1021/jm00072a024 | Pancreatic alpha-amylase | 1 |
Data from ChEMBL 36 via Core Engine