Assay Detail
Binding
CHEMBL653980
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Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.01 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 9.54 |
| CHEMBL274661 | — | — | 1 | 8.70 |
| CHEMBL441165 | — | — | 1 | 8.00 |
| CHEMBL216079 | — | — | 1 | 7.50 |
| CHEMBL262155 | — | — | 1 | 7.24 |
| CHEMBL217424 | — | — | 1 | 6.70 |
| CHEMBL217234 | — | — | 1 | 6.69 |
| CHEMBL386811 | — | — | 1 | 6.30 |
| CHEMBL263876 | — | — | 1 | 5.94 |
| CHEMBL444113 | — | — | 1 | 5.92 |
| CHEMBL385918 | — | — | 1 | 5.78 |
| CHEMBL414180 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL274661 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL441165 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL216079 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL262155 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL217424 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL217234 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL386811 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL263876 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL444113 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL385918 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL414180 | — | IC50 | = | 1750.0 | nM | 5.76 |