Assay Detail
Binding
CHEMBL662474
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Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.88 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 8.64 |
| CHEMBL274661 | — | — | 1 | 8.52 |
| CHEMBL216079 | — | — | 1 | 7.92 |
| CHEMBL262155 | — | — | 1 | 7.89 |
| CHEMBL263876 | — | — | 1 | 7.85 |
| CHEMBL217234 | — | — | 1 | 7.82 |
| CHEMBL217424 | — | — | 1 | 7.80 |
| CHEMBL414180 | — | — | 1 | 7.75 |
| CHEMBL444113 | — | — | 1 | 7.64 |
| CHEMBL441165 | — | — | 1 | 7.52 |
| CHEMBL385918 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL274661 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL216079 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL262155 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL263876 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL217234 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL217424 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL414180 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL444113 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL441165 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL385918 | — | IC50 | = | 42.0 | nM | 7.38 |