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Assay Detail

CHEMBL649527

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition constant of compound on ligand binding to aggregates of Amyloid beta was measured by comparing with [125I]IMSB
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Zhuang ZP, Kung MP, Hou C, Skovronsky DM, Gur TL, Plössl K, Trojanowski JQ, Lee VM, Kung HF.
J Med Chem (2001) 44 : 1905 -1914
PubMed 11384236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.40 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300172 CHRYSAMINE G 1 9.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300172 CHRYSAMINE G Ki = 0.4 nM 9.40