Assay Detail
Binding
CHEMBL649528
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Inhibition constant for amyloid beta compared to [125I]TZDM
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.26 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55401 | — | — | 2 | 9.10 |
| CHEMBL55380 | — | — | 2 | 9.05 |
| CHEMBL55536 | — | — | 2 | 8.80 |
| CHEMBL58092 | — | — | 2 | 8.27 |
| CHEMBL57267 | — | — | 2 | 6.94 |
| CHEMBL292910 | — | — | 2 | - |
| CHEMBL300172 | CHRYSAMINE G | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55401 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL55380 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL55536 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL55401 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL55380 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL55536 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL58092 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL58092 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL57267 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL57267 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL292910 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL292910 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL300172 | CHRYSAMINE G | Ki | > | 1000.0 | nM | - |