Assay Detail
Binding
CHEMBL649529
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Inhibition constant for aggregates of amyloid beta compared to [125I]IMSB
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.57 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300172 | CHRYSAMINE G | — | 1 | 9.85 |
| CHEMBL292910 | — | — | 2 | 9.77 |
| CHEMBL55380 | — | — | 2 | - |
| CHEMBL58092 | — | — | 2 | - |
| CHEMBL55401 | — | — | 2 | - |
| CHEMBL57267 | — | — | 2 | - |
| CHEMBL55536 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300172 | CHRYSAMINE G | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL292910 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL292910 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL55380 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL55380 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL58092 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL58092 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL55401 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL55401 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL57267 | — | Ki | > | 9000.0 | nM | - |
| CHEMBL57267 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL55536 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL55536 | — | Ki | > | 2400.0 | nM | - |