Assay Detail
Functional
CHEMBL649532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Angiotensin II receptor type 1 in rat uterus
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Uterus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Structural comparison between type I and type II antagonists: possible implications in the drug design of AT1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.83 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 8.10 |
| CHEMBL350715 | — | — | 1 | 7.80 |
| CHEMBL2371021 | — | — | 1 | 7.50 |
| CHEMBL216533 | — | — | 1 | 6.70 |
| CHEMBL2371453 | — | — | 1 | 6.60 |
| CHEMBL166204 | — | — | 1 | 5.70 |
| CHEMBL264335 | — | — | 1 | 5.40 |
| CHEMBL349256 | — | — | 1 | - |
| CHEMBL350132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL350715 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL2371021 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL216533 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL2371453 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL166204 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL264335 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL349256 | — | Kd | > | 15848.93 | nM | - |
| CHEMBL350132 | — | Kd | > | 15848.93 | nM | - |