Assay Detail
Functional
CHEMBL649534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat liver using [125I]-Sar1-Ile8-Ang II as radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Liver |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.15 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305544 | SAPRISARTAN | 2.0 | 1 | 9.30 |
| CHEMBL304639 | ZOLASARTAN | 2.0 | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305544 | SAPRISARTAN | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL304639 | ZOLASARTAN | Ki | = | 1.0 | nM | 9.00 |