Assay Detail
Binding
CHEMBL649535
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Inhibitory concentration against Angiotensin II receptor, type 1 was measured through displacement of [125I]-Ang II in rat liver membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.83 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288174 | — | — | 1 | 8.96 |
| CHEMBL290214 | — | — | 1 | 8.85 |
| CHEMBL39959 | — | — | 1 | 8.82 |
| CHEMBL289614 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288174 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL290214 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL39959 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL289614 | — | IC50 | = | 2.1 | nM | 8.68 |