Assay Detail
Binding
CHEMBL649536
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Binding affinity at Angiotensin II receptor, type 1 in rat liver membranes by [125I]-Ang II displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.80 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288174 | — | — | 1 | 8.41 |
| CHEMBL289306 | — | — | 1 | 7.47 |
| CHEMBL39132 | — | — | 1 | 7.46 |
| CHEMBL40563 | — | — | 1 | 7.26 |
| CHEMBL290370 | — | — | 1 | 7.21 |
| CHEMBL415875 | — | — | 1 | 6.96 |
| CHEMBL291089 | — | — | 1 | 6.92 |
| CHEMBL432095 | — | — | 1 | 6.73 |
| CHEMBL291124 | — | — | 1 | 6.64 |
| CHEMBL290708 | — | — | 1 | 6.61 |
| CHEMBL289211 | — | — | 1 | 6.47 |
| CHEMBL409843 | — | — | 1 | 6.46 |
| CHEMBL289775 | — | — | 1 | 6.39 |
| CHEMBL291125 | — | — | 1 | 6.34 |
| CHEMBL287829 | — | — | 1 | 6.16 |
| CHEMBL289803 | — | — | 1 | 6.14 |
| CHEMBL38842 | — | — | 1 | 5.98 |
| CHEMBL277388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288174 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL289306 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL39132 | — | Ki | = | 34.9 | nM | 7.46 |
| CHEMBL40563 | — | Ki | = | 55.2 | nM | 7.26 |
| CHEMBL290370 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL415875 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL291089 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL432095 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL291124 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL290708 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL289211 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL409843 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL289775 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL291125 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL287829 | — | Ki | = | 693.0 | nM | 6.16 |
| CHEMBL289803 | — | Ki | = | 728.0 | nM | 6.14 |
| CHEMBL38842 | — | Ki | = | 1038.0 | nM | 5.98 |
| CHEMBL277388 | — | Ki | > | 10000.0 | nM | - |