Assay Detail
Functional
CHEMBL649557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of antagonist activity towards Androgen receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.86 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.08 |
| CHEMBL64294 | — | — | 1 | 7.22 |
| CHEMBL62227 | — | — | 1 | 7.22 |
| CHEMBL293409 | — | — | 1 | 7.20 |
| CHEMBL62761 | — | — | 1 | 7.05 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 6.57 |
| CHEMBL63870 | — | — | 1 | 6.40 |
| CHEMBL64123 | — | — | 1 | 6.10 |
| CHEMBL65079 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL64294 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL62227 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL293409 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL62761 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL63870 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL64123 | — | IC50 | = | 788.0 | nM | 6.10 |
| CHEMBL65079 | — | IC50 | = | 1248.0 | nM | 5.90 |