Assay Detail
Functional
CHEMBL649561
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Cross-reactivity as binding to human androgen receptor (hAR)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.44 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134260 | — | — | 1 | 7.35 |
| CHEMBL132889 | — | — | 1 | 6.82 |
| CHEMBL131855 | — | — | 1 | 6.70 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 6.57 |
| CHEMBL335992 | — | — | 1 | 6.31 |
| CHEMBL132193 | — | — | 1 | 5.96 |
| CHEMBL131681 | — | — | 1 | 5.96 |
| CHEMBL133656 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134260 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL132889 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL131855 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL335992 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL132193 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL131681 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL133656 | — | IC50 | = | 1460.0 | nM | 5.84 |