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Assay Detail

CHEMBL649590

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tissue alpha-L-fucosidase (CHEMBL4176)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives.
Robina I, Moreno-Vargas AJ, Fernández-Bolaños JG, Fuentes J, Demange R, Vogel P.
Bioorg Med Chem Lett (2001) 11 : 2555 -2559
PubMed 11549468 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 5.90 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL87463 1 8.30
CHEMBL84647 1 8.00
CHEMBL85218 1 7.80
CHEMBL85846 1 6.80
CHEMBL314277 1 6.64
CHEMBL85171 1 6.17
CHEMBL313893 1 6.09
CHEMBL1289015 1 5.85
CHEMBL314405 1 5.70
CHEMBL1160549 1 5.55
CHEMBL314581 1 5.48
CHEMBL431802 1 5.40
CHEMBL86305 1 5.08
CHEMBL1289017 1 5.05
CHEMBL314650 1 4.82
CHEMBL313657 1 4.62
CHEMBL85817 1 4.52
CHEMBL313531 1 4.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL87463 Ki = 5.0 nM 8.30
CHEMBL84647 Ki = 10.0 nM 8.00
CHEMBL85218 Ki = 16.0 nM 7.80
CHEMBL85846 Ki = 160.0 nM 6.80
CHEMBL314277 Ki = 230.0 nM 6.64
CHEMBL85171 Ki = 680.0 nM 6.17
CHEMBL313893 Ki = 820.0 nM 6.09
CHEMBL1289015 Ki = 1400.0 nM 5.85
CHEMBL314405 Ki = 2000.0 nM 5.70
CHEMBL1160549 Ki = 2800.0 nM 5.55
CHEMBL314581 Ki = 3300.0 nM 5.48
CHEMBL431802 Ki = 4000.0 nM 5.40
CHEMBL86305 Ki = 8400.0 nM 5.08
CHEMBL1289017 Ki = 9000.0 nM 5.05
CHEMBL314650 Ki = 15000.0 nM 4.82
CHEMBL313657 Ki = 24000.0 nM 4.62
CHEMBL85817 Ki = 30000.0 nM 4.52
CHEMBL313531 Ki = 42000.0 nM 4.38