Assay Detail
Binding
CHEMBL649613
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Inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.12 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.04 |
| CHEMBL72292 | — | — | 1 | 7.92 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.75 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.19 |
| CHEMBL72794 | — | — | 1 | 6.92 |
| CHEMBL73074 | — | — | 1 | 6.62 |
| CHEMBL308090 | — | — | 1 | 6.58 |
| CHEMBL70377 | — | — | 1 | 5.92 |
| CHEMBL310712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL72292 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL72794 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL73074 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL308090 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL70377 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL310712 | — | IC50 | > | 1000.0 | nM | - |