Assay Detail
Binding
CHEMBL649614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against radioligand [3H]-WB- 4101 binding to rat cortical Alpha-1 adrenergic receptor
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60859 | BMY-14802 | — | 2 | 6.34 |
| CHEMBL129768 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60859 | BMY-14802 | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL129768 | — | IC50 | = | 610.0 | nM | 6.21 |