Assay Detail
Binding
CHEMBL649628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor in rat frontal cortex homogenate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.17 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.89 |
| CHEMBL368324 | — | — | 1 | 6.68 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.57 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL368324 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL715 | OLANZAPINE | Ki | = | 2870.0 | nM | 5.54 |