Assay Detail
Binding
CHEMBL649641
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In vitro binding affinity was measured as the inhibition of [3H]idazoxan to alpha-2 adrenergic receptors of rat cortical membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.19 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29001 | — | — | 1 | 7.85 |
| CHEMBL31548 | — | — | 1 | 7.01 |
| CHEMBL28448 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29001 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL31548 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL28448 | — | Ki | = | 200.0 | nM | 6.70 |