Assay Detail
Binding
CHEMBL649644
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Inhibition of [3H]- rauwolscine binding to alpha-2 adrenergic receptor in membrane of rat cerebral cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New potential uroselective NO-donor alpha1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.98 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338608 | — | — | 1 | 7.27 |
| CHEMBL125989 | — | — | 1 | 7.09 |
| CHEMBL338029 | — | — | 1 | 7.09 |
| CHEMBL125365 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338608 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL125989 | — | Ki | = | 81.1 | nM | 7.09 |
| CHEMBL338029 | — | Ki | = | 81.8 | nM | 7.09 |
| CHEMBL125365 | — | Ki | = | 359.0 | nM | 6.45 |