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Assay Detail

CHEMBL649693

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Aldo-keto reductase family 1 member B1 (CHEMBL3081)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Spiro hydantoin aldose reductase inhibitors.
Sarges R, Schnur RC, Belletire JL, Peterson MJ.
J Med Chem (1988) 31 : 230 -243
PubMed 3121857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.00 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63055 ALRESTATIN 2.0 1 5.00
CHEMBL81310 1 5.00
CHEMBL81641 1 5.00
CHEMBL310731 1 5.00
CHEMBL81029 1 5.00
CHEMBL81032 1 5.00
CHEMBL443271 1 5.00
CHEMBL82242 QUERCITRIN 1 5.00
CHEMBL79485 1 5.00
CHEMBL439947 1 5.00
CHEMBL79255 1 5.00
CHEMBL79430 1 5.00
CHEMBL80679 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63055 ALRESTATIN IC50 = 10000.0 nM 5.00
CHEMBL81310 IC50 = 10000.0 nM 5.00
CHEMBL81641 IC50 = 10000.0 nM 5.00
CHEMBL310731 IC50 = 10000.0 nM 5.00
CHEMBL81029 IC50 = 10000.0 nM 5.00
CHEMBL81032 IC50 = 10000.0 nM 5.00
CHEMBL443271 IC50 = 10000.0 nM 5.00
CHEMBL82242 QUERCITRIN IC50 = 10000.0 nM 5.00
CHEMBL79485 IC50 = 10000.0 nM 5.00
CHEMBL439947 IC50 = 10000.0 nM 5.00
CHEMBL79255 IC50 = 10000.0 nM 5.00
CHEMBL79430 IC50 = 10000.0 nM 5.00
CHEMBL80679 IC50 = 10000.0 nM 5.00