Assay Detail
Binding
CHEMBL649694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Spiro hydantoin aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312392 | — | — | 1 | 6.00 |
| CHEMBL307847 | — | — | 1 | 6.00 |
| CHEMBL81027 | — | — | 1 | 6.00 |
| CHEMBL81456 | — | — | 1 | 6.00 |
| CHEMBL312509 | — | — | 1 | 6.00 |
| CHEMBL80679 | — | — | 1 | 6.00 |
| CHEMBL420024 | — | — | 1 | 6.00 |
| CHEMBL78803 | — | — | 1 | 6.00 |
| CHEMBL83689 | — | — | 1 | 6.00 |
| CHEMBL81601 | — | — | 1 | 6.00 |
| CHEMBL32799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312392 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL307847 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL81027 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL81456 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL312509 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL80679 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL420024 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL78803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL83689 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL81601 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL32799 | — | IC50 | = | 1000.0 | nM | - |