Assay Detail
Binding
CHEMBL649695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.28 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.46 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.82 |
| CHEMBL63055 | ALRESTATIN | 2.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL266497 | SORBINIL | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL63055 | ALRESTATIN | IC50 | = | 2700.0 | nM | 5.57 |