Assay Detail
Binding
CHEMBL649733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286008 | — | — | 1 | 8.00 |
| CHEMBL284137 | — | — | 1 | 7.68 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 7.34 |
| CHEMBL443780 | — | — | 1 | 7.28 |
| CHEMBL285440 | — | — | 1 | 6.72 |
| CHEMBL285898 | — | — | 1 | 6.42 |
| CHEMBL24369 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286008 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL284137 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL26505 | APROFENE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL443780 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL285440 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL285898 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL24369 | — | IC50 | = | 2700.0 | nM | 5.57 |