Assay Detail
Binding
CHEMBL649738
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Compound was evaluated for inactivation of bovine alpha-Chymotrypsin Kinetic constant(Ki)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.73 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108294 | — | — | 1 | 8.35 |
| CHEMBL111705 | — | — | 1 | 7.16 |
| CHEMBL320132 | — | — | 1 | 6.47 |
| CHEMBL110995 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108294 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL111705 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL320132 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL110995 | — | Ki | = | 12000.0 | nM | 4.92 |